sorry. I sent a false message yesterday。I try again today. even upgrade to Org mode version 9.5.3 (9.5.3-g277897), The problem still exists. But I find out something new。you can see my conclusion. And I send all my emacs org state.

- desktop environment
- GNU Emacs 29.0.50 (build 2, x86_64-apple-darwin20.4.0, NS appkit-2022.44 Version 11.3.1 (Build 20E241)) of 2022-01-08
- Org mode version 9.5.3 (9.5.3-g277897)
- bug description
- influence factor
- a large org file : 11053 lines。1092 headlines。
- (setq org-startup-folded t)
- org-indent-mode : (add-hook 'org-mode-hook 'org-indent-mode)
- My Observation
- if setting org-startup-folded t , enable org-indent-mode, open the large org file, emacs get stuck, the mouse can't move。
- if keeping org-startup-folded defaul value（i.e "showeverything") , enable org-indent-mode , open the large org file, get a warning, but not get stuck:
#+begin_quote
Warning (org-element-cache): org-element--cache: Unregistered buffer modifications detected. Resetting.
If this warning appears regularly, please report it to Org mode mailing list (M-x org-submit-bug-report).
#+end_quote
- if keeping org-startup-folded defaul value and disable org-indent-mode , open the large org file, everything works fine.
- if setting org-startup-folded t, disable org-indent-mode, everything works fine.
- conclusion
- enalbe org-indent-mode cause the warning : "Warning (org-element-cache): org-element--cache: Unregistered buffer modifications detected."
- setting org-startup-folded t, enable org-indent-mode. Having both causes emacs get stuck.

- In addition，it's not accurate to say that emacs get stuck. To be precise, emacs get stuck, the mouse can't move for a few seconds and then it works find.

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Emacs : GNU Emacs 29.0.50 (build 2, x86_64-apple-darwin20.4.0, NS appkit-2022.44 Version 11.3.1 (Build 20E241))
of 2022-01-08
Package: Org mode version 9.5.3 (9.5.3-g277897 @ /Users/fuhongxue/env/emacs/vanilla/straight/straight/build/org/)

current state:
==============
(setq
org-roam-db-location "~/central-management-system/zotero/roam-db/2022-03-13-daily-based.db"
org-link-elisp-confirm-function 'yes-or-no-p
org-hide-emphasis-markers t
org-bibtex-headline-format-function #[257 "\300 \236A\207" [:title] 3 "\n\n(fn ENTRY)"]
org-download-file-format-function 'org-download-file-format-default
org-roam-dailies-capture-templates '(("d" "default" entry "* %<%Y-%m-%d %H:%M> %?" :if-new
(file+head "%<%Y-%m-%d>.org" "#+title: %<%Y-%m-%d>\n#+filetags: :daily:\n"))
)
org-startup-folded t
org-roam-node-display-template "${tags:35} ${title:80}"
org-persist-after-read-hook '(org-element--cache-persist-after-read)
org-export-before-parsing-hook '(org-attach-expand-links)
org-cycle-tab-first-hook '(org-babel-hide-result-toggle-maybe org-babel-header-arg-expand)
org-tag-alist '(("review" . 114) ("summary" . 115) ("case" . 99) ("book" . 98) ("economics" . 101) ("refile" . 114) ("twitter" . 116) ("youtube" . 121)
("emacs" . 101) ("weibo" . 119) ("how" . 104))
org-roam-find-file-hook '(org-roam-buffer--setup-redisplay-h org-roam--register-completion-functions-h org-roam--replace-roam-links-on-save-h
org-roam-db-autosync--setup-update-on-save-h)
org-archive-hook '(org-attach-archive-delete-maybe)
org-footnote-auto-adjust t
org-odt-format-inlinetask-function 'org-odt-format-inlinetask-default-function
org-ascii-format-drawer-function #[771 " \207" [] 4 "\n\n(fn NAME CONTENTS WIDTH)"]
org-cycle-hook '(org-cycle-hide-archived-subtrees org-cycle-show-empty-lines org-cycle-optimize-window-after-visibility-change)
org-persist-before-read-hook '(org-element--cache-persist-before-read)
org-font-lock-set-keywords-hook '(doom-themes-enable-org-fontification)
org-image-actual-width nil
org-mode-hook '(rasmus/org-prettify-symbols org-fragtog-mode org-indent-mode valign-mode
#[0 "\300\301\302\303\304$\207" [add-hook change-major-mode-hook org-fold-show-all append local] 5]
#[0 "\300\301\302\303\304$\207" [add-hook change-major-mode-hook org-babel-show-result-all append local] 5] org-babel-result-hide-spec
org-babel-hide-all-hashes)
org-roam-ref-annotation-function 'org-roam-ref-read--annotation
org-roam-directory "~/central-management-system/zotero/notes/2022-03-13-daily-based"
org-latex-format-drawer-function #[514 "\207" [] 3 "\n\n(fn _ CONTENTS)"]
org-download-timestamp "%Y%m%d-%H%M%S_"
org-roam-db-node-include-function #[0 "\300\207" [t] 1]
org-download-abbreviate-filename-function 'file-relative-name
org-latex-format-headline-function 'org-latex-format-headline-default-function
org-confirm-shell-link-function 'yes-or-no-p
org-download-annotate-function '(closure (t) (_link) "")
org-html-format-drawer-function #[514 "\207" [] 3 "\n\n(fn NAME CONTENTS)"]
outline-isearch-open-invisible-function 'outline-isearch-open-invisible
org-roam-dailies-directory "~/central-management-system/zotero/notes/2022-05-10-theme/daily"
org-latex-classes '(("org-plain-latex" "\\documentclass{article}[102pt,letterpaper]\n \\tolerance=1000\n [NO-DEFAULT-PACKAGES]\n [EXTRA]"
("\\section{%s}" . "\\section*{%s}") ("\\subsection{%s}" . "\\subsection*{%s}") ("\\subsubsection{%s}" . "\\subsubsection*{%s}")
("\\paragraph{%s}" . "\\paragraph*{%s}") ("\\subparagraph{%s}" . "\\subparagraph*{%s}"))
("article" "\\documentclass[11pt]{article}" ("\\section{%s}" . "\\section*{%s}") ("\\subsection{%s}" . "\\subsection*{%s}")
("\\subsubsection{%s}" . "\\subsubsection*{%s}") ("\\paragraph{%s}" . "\\paragraph*{%s}")
("\\subparagraph{%s}" . "\\subparagraph*{%s}"))
("report" "\\documentclass[11pt]{report}" ("\\part{%s}" . "\\part*{%s}") ("\\chapter{%s}" . "\\chapter*{%s}")
("\\section{%s}" . "\\section*{%s}") ("\\subsection{%s}" . "\\subsection*{%s}") ("\\subsubsection{%s}" . "\\subsubsection*{%s}"))
("book" "\\documentclass[11pt]{book}" ("\\part{%s}" . "\\part*{%s}") ("\\chapter{%s}" . "\\chapter*{%s}")
("\\section{%s}" . "\\section*{%s}") ("\\subsection{%s}" . "\\subsection*{%s}") ("\\subsubsection{%s}" . "\\subsubsection*{%s}"))
)
org-odt-format-headline-function 'org-odt-format-headline-default-function
org-roam-capture-preface-hook '(org-roam-dailies--override-capture-time-h org-roam-capture--try-capture-to-ref-h)
org-agenda-before-write-hook '(org-agenda-add-entry-text)
org-capture-prepare-finalize-hook '(org-roam-capture--install-finalize-h)
org-roam-preview-function 'org-roam-preview-default-function
org-src-mode-hook '(doom-modeline-set-org-src-modeline org-src-babel-configure-edit-buffer org-src-mode-configure-edit-buffer)
org-confirm-elisp-link-function 'yes-or-no-p
org-latex-src-block-backend t
org-log-buffer-setup-hook '(org-roam-log--setup)
org-roam-capture-new-node-hook '(org-roam-capture--insert-captured-ref-h)
org-preview-latex-image-directory "/Users/fuhongxue/env/emacs/cache/"
org-speed-command-hook '(org-speed-command-activate org-babel-speed-command-activate)
org-html-format-inlinetask-function 'org-html-format-inlinetask-default-function
org-ascii-format-inlinetask-function 'org-ascii-format-inlinetask-default
org-odt-format-drawer-function #[514 "\207" [] 3 "\n\n(fn NAME CONTENTS)"]
org-fold-core-isearch-open-function 'org-fold--isearch-reveal
org-preview-latex-default-process 'dvisvgm
org-latex-format-inlinetask-function 'org-latex-format-inlinetask-default-function
org-persist-before-write-hook '(org-element--cache-persist-before-write)
org-tab-first-hook '(org-babel-hide-result-toggle-maybe org-babel-header-arg-expand)
org-link-shell-confirm-function 'yes-or-no-p
org-babel-pre-tangle-hook '(save-buffer)
org-agenda-loop-over-headlines-in-active-region nil
org-cycle-include-plain-lists 'integrate
org-occur-hook '(org-first-headline-recenter)
org-roam-log-setup-hook '(org-roam--register-completion-functions-h)
org-metadown-hook '(org-babel-pop-to-session-maybe)
org-roam-node-annotation-function 'org-roam-node-read--annotation
org-link-parameters '(("eww" :follow org-eww-open :store org-eww-store-link) ("rmail" :follow org-rmail-open :store org-rmail-store-link)
("mhe" :follow org-mhe-open :store org-mhe-store-link)
("irc" :follow org-irc-visit :store org-irc-store-link :export org-irc-export)
("info" :follow org-info-open :export org-info-export :store org-info-store-link)
("gnus" :follow org-gnus-open :store org-gnus-store-link)
("docview" :follow org-docview-open :export org-docview-export :store org-docview-store-link)
("bibtex" :follow org-bibtex-open :store org-bibtex-store-link)
("bbdb" :follow org-bbdb-open :export org-bbdb-export :complete org-bbdb-complete-link :store org-bbdb-store-link)
("w3m" :store org-w3m-store-link) ("doi" :follow org-link-doi-open :export org-link-doi-export)
("roam" :follow org-roam-link-follow-link) ("attachment" :follow org-attach-follow :complete org-attach-complete-link)
("id" :follow org-roam-id-open) ("file+sys") ("file+emacs") ("shell" :follow org-link--open-shell)
("news" :follow #[514 "\301\300\302 Q \"\207" ["news" browse-url ":"] 6 "\n\n(fn URL ARG)"])
("mailto" :follow #[514 "\301\300\302 Q \"\207" ["mailto" browse-url ":"] 6 "\n\n(fn URL ARG)"])
("https" :follow #[514 "\301\300\302 Q \"\207" ["https" browse-url ":"] 6 "\n\n(fn URL ARG)"])
("http" :follow #[514 "\301\300\302 Q \"\207" ["http" browse-url ":"] 6 "\n\n(fn URL ARG)"])
("ftp" :follow #[514 "\301\300\302 Q \"\207" ["ftp" browse-url ":"] 6 "\n\n(fn URL ARG)"])
("help" :follow org-link--open-help :store org-link--store-help) ("file" :complete org-link-complete-file)
("elisp" :follow org-link--open-elisp))
org-roam-ui-browser-function 'browse-url
org-html-format-headline-function 'org-html-format-headline-default-function
org-metaup-hook '(org-babel-load-in-session-maybe)
org-download-heading-lvl nil
org-download-link-format-function 'org-download-link-format-function-default
org-link-frame-setup '((file . find-file))
org-download-image-dir "images/"
org-roam-indirect-buffer-hook '(org-roam--register-completion-functions-h)
)