In the source code directory of Guix, when trying to build a package from gnu/packages/python-xyz.scm, it fails with the following error:

guix build: error: /storage/src/guix/guix-gnu/guix/build-system/gnu.scm:146:8: package `guile@3.0.9' has an invalid input: ("_" #<syntax-transformer pkg-config>)

For example:

guix build -L $(pwd) -e "(begin (use-modules (gnu packages python-xyz)) poetry)"

guix build -L $(pwd) -e "(begin (use-modules (gnu packages python-xyz)) python-lsp-server)"

It fails for all packages in python-xyz.scm. But you can build other packages:
guix build -L $(pwd) -e "(begin (use-modules (gnu packages any-other)) program)"

/ Paul