From mboxrd@z Thu Jan  1 00:00:00 1970
From: David Craven <david@craven.ch>
Subject: Re: Size of bare-bones guixsd
Date: Sat, 6 Aug 2016 18:28:03 +0200
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To: help-guix@gnu.org, Vincent Legoll <vincent.legoll@gmail.com>

> I know these probably come from indirect dependencies of other tools,
> for advanced features... (please remember that I come with a long
> background of gentoo negated use flags)
>
> libXpm, cairo, libxcb, randrproto, glibmm, randrproto, mkfontscale,
> inputproto, imagemagick, xtrans, gtk+, compositeproto, cups*, inkscape,
> xextproto, freetype, libXrender, gdk-pixbuf, libxcb, libXdmcp, libXaw,
> xcb-proto, pixman, netpbm, libvorbis, libcddb, openjpeg, atkmm, libxmu,
> libx11, etc...

Could it be that these are dependencies of wacom which is a dependency
of libinput? In that case you can try replacing libinput with libinput-minimal.

David