guix system vm /etc/vm-config-desktop.scm \
>    --image-size=30GB \
>    --expose=$HOME \
>    --share=$HOME/share=/exchange

I get this

;;; WARNING: loading compiled file /home/catonano/.config/guix/latest/guix/ui.go failed:
;;; ERROR: In procedure load-thunk-from-memory: not an ELF file
;;; WARNING: loading compiled file /home/catonano/.config/guix/latest/guix/gexp.go failed:
;;; ERROR: In procedure load-thunk-from-memory: not an ELF file
;;; WARNING: loading compiled file /home/catonano/.config/guix/latest/guix/store.go failed:
;;; ERROR: In procedure load-thunk-from-memory: not an ELF file
;;; WARNING: loading compiled file /home/catonano/.config/guix/latest/guix/utils.go failed:
;;; ERROR: In procedure load-thunk-from-memory: not an ELF file
....

and many more

was the "latest" guix compiled with an old guile ?