I had this line in my emacs config (set-frame-font "DejaVu Sans Mono-18" nil t) now it seems that the DeaVu font is not available anymore error: Font not available, # It was ! Until a not so long time ago ! AND it is installed ! In fact: $ guix package --list-installed glibc-locales 2.23 out /gnu/store/dnng2ign15r1223mp2sxvr93qc7550dr-glibc-locales-2.23 nss-certs 3.26 out /gnu/store/4ij62g7004092sv9qm81xaxx8g3cpgnl-nss-certs-3.26 emacs 25.1 out /gnu/store/d0fs2clgrf6hg8nxazkxwvadpg8nw18d-emacs-25.1 guix 0.11.0-1.4420 out /gnu/store/wvj056mfbqid88q2l119kb3mwicii0i6-guix-0.11.0-1.4420 emacs-zenburn-theme 2.4 out /gnu/store/7ln18hnahnbkqlblgswcp3viqbckmiw3-emacs-zenburn-theme-2.4 emacs-smartparens 1.7.1 out /gnu/store/45j382p6lyrp3xq2d62b95dbwdgn6mn7-emacs-smartparens-1.7.1 geiser-next 0.8.1-12e33569 out /gnu/store/v4aswzzgp6fz7lknxhbkib1x5bykq94p-geiser-next-0.8.1-12e33569 font-dejavu 2.35 out /gnu/store/1k1aip21m3zgq2x89dbwv5kirclcqbvv-font-dejavu-2.35 font-liberation 2.00.1 out /gnu/store/dv5h6z84fgpaxxr2cjvrpmh28l0avnr2-font-liberation-2.00.1 gedit 3.20.1 out /gnu/store/gd9pxg3z0pr1civ2ksjrkxzxcivf511r-gedit-3.20.1