Dear Oleg, At that time, spice-vdagent package had a bug. So I modified spice.scm to fix it. To make it applied to the system, I put that file into ~/my-guix/gnu/packages and ran `guix system reconfigure /etc/config.scm -L ~/my-guix`. But it took long time because there were many packages to be built without substitutes. So I just did dry-run. Now, spice-vdagent's bug is fixed. Thus, just for test, I modified the spice.scm in ~/my-guix/gnu/packages and try reconfiguring the system. Spice.scm is modified as: --- spice.scm.orig 2018-11-19 04:05:33.543753567 +0900 +++ spice.scm 2018-11-19 03:09:09.283971057 +0900 @@ -252,7 +252,7 @@ (substitute* "data/spice-vdagent.desktop" (("Exec=/usr/bin/spice-vdagent") (string-append "Exec=" (assoc-ref outputs "out") - "/bin/spice-vdagent"))) + "/bin/spice-vdagent\n"))) #t))))) (inputs `(("alsa-lib" ,alsa-lib) I have dry-run's. [1] guix system reconfigure /etc/config.scm -n -L ~/my-guix : with_spice_with_loadpath.log (12K) [2] export GUIX_PACKAGE_PATH=~/my-guix; guix system reconfigure /etc/config.scm -n : with_spice_with_guix_package_path.log (15K) I think the two should give the same output. But as you see, those are different. First, [1] does not have commented lines: ;;; note: source file /root/my-guix/gnu/packages/spice.scm ;;; newer than compiled /gnu/store/k7lvym1xl87p156jd459k36ddbb1msvm-guix-a7b7d48cc-modules/gnu/packages/spice.go ;;; note: source file /root/my-guix/gnu/packages/spice.scm ;;; newer than compiled /run/current-system/profile/lib/guile/2.2/site-ccache/gnu/packages/spice.go And derivations to be built and packages to be downloaded are different. But the same test for 'guix build' is positive. build_with_spice_with_loadpath.log (2K) build_with_spice_with_guix_package_path.log (2K) Finally, I have real build run's. [3] guix system reconfigure /etc/conf.scm -L ~/my-guix : real_with_spice_with_loadpath.log (10K) [4] export GUIX_PACKAGE_PATH=~/my-guix; guix system reconfigure /etc/config.scm real_with_spice_with_guix_package_path.log (12K) Run [3] does not build spice-vdagent, but just grub.cfg. Run [4] does what I want. Only [4] makes change in /run/current-system/profile/etc/xdg/autostart/spice-vdagent.desktop . Regards, Taegil