>> /home/arunisaac/.guix-profile: symbolic link to /home/arunisaac/.guix-profile-2-link
>
> That looks unusual to me.

I created a new test user (to get a guix-profile from scratch), and
there was no issue with transmission-remote-cli. Maybe, I should just
delete my ~/.guix-profile and ~/.guix-profile-2-link on user 'arunisaac'
and start from scratch.

> $ file ~/.guix-profile
> /home/leo/.guix-profile: symbolic link to /var/guix/profiles/per-user/leo/guix-profile
>
> It would be interesting to see the full chain of symlinks.

The full chain of symlinks are as follows.

$ file ~/.guix-profile

.guix-profile: symbolic link to /home/arunisaac/.guix-profile-2-link

$ file ~/.guix-profile-2-link

/home/arunisaac/.guix-profile-2-link: symbolic link to /gnu/store/8q44nc4vgljkxm3bsbvq9gqln6lqqm85-profile

$ file /gnu/store/8q44nc4vgljkxm3bsbvq9gqln6lqqm85-profile/

/gnu/store/8q44nc4vgljkxm3bsbvq9gqln6lqqm85-profile/: directory

Thank you! :-)