> Does that make sense?

Absolutely, but it gets trickier when trying to run a 32-bit executable
which was not compiled on Guix.

Any idea how to achieve that easily?

The way I can think of for now is to run patchelf against the binary to
change the dynamic linker path as well as the RPATH.

--
Pierre Neidhardt

Depart in pieces, i.e., split.