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(At least, enough to move forward with what I'm trying to do.) The Guile package in Guix isn't configured to look in GUILE_EXTENSIONS_PATH for native extensions. I managed to work around this by doing this in a manifest for my project: #+begin_src scheme (define-public guile-search (package (inherit guile-3.0) (native-search-paths (list (search-path-specification (variable "GUILE_EXTENSIONS_PATH") (files (list "lib/guile/3.0/extensions"))))))) #+end_src That said... is there a reason the Guile package doesn't already look here by default?