It should help when cross-compiling several ‘cargo-build-system’ packages:

--8<---------------cut here---------------start------------->8---
$ time GUIX_PROFILING=object-cache guix build --no-grafts greetd wlgreet du-dust circtools --target=aarch64-linux-gnu -d # before
/gnu/store/mivzv83wryv9gp5bjncg5m1831dx2xwr-circtools-1.0.0.drv
/gnu/store/4xf7kh9mi0vpvs8m1ak4x8w1rpsdpv6z-du-dust-0.8.6.drv
/gnu/store/ayk54gvlbc1qam6irzf9kaig56dhzni0-wlgreet-0.4.1.drv
/gnu/store/r601i40cii9ic5w1k4hy5c2yngfayh64-greetd-0.9.0.drv
Object Cache:
  fresh caches:    22
  lookups:      40435
  hits:         36821 (91.1%)
  cache size:    3613 entries

real	0m2.964s
user	0m2.925s
sys	0m0.174s
$ time GUIX_PROFILING=object-cache ./pre-inst-env guix build --no-grafts greetd wlgreet du-dust circtools --target=aarch64-linux-gnu -d # after
/gnu/store/1wsldmvigjb8w2gk418npbnfznlb0ck1-circtools-1.0.0.drv
/gnu/store/b5c73fawjdvkgy431qxz9l6l9y9a9lhz-du-dust-0.8.6.drv
/gnu/store/zwc7qzsbzf62dgbbzy74lki4hsr406bw-wlgreet-0.4.1.drv
/gnu/store/vjdd23hc82701afb132z1ajcqa7hfd74-greetd-0.9.0.drv
Object Cache:
  fresh caches:    22
  lookups:      37942
  hits:         34523 (91.0%)
  cache size:    3418 entries

real	0m2.980s
user	0m3.300s
sys	0m0.160s
--8<---------------cut here---------------end--------------->8---

(Here we removed ~2.5k nodes from the cache.)

WDYT?

Ludo’.