Hello! Finally it succeeded. Thanks to everyone who has answered my countless questions on the mailing list and IRC! GNU Hello - /gnu/store/98wc63drnc5iwkcclls91iz181mmiv7c-hello-2.10 (natively built with: ./pre-inst-env guix build hello) I used Gentoo (https://wiki.gentoo.org/wiki/Handbook:PPC64) as a base PowerPC 64-bit big endian system. (precisely IBM POWER9) source: https://gitlab.com/lle-bout/guix - commit f47e761a10675b05b07107035d5024618267a3ad (current master at time of writing) bootstrap binaries: https://gitlab.com/lle-bout/guix-bootstrap - commit b017c0459bc65a53203eb056998be8abd7778e4a (current master at time of writing) - currently it's unclear from which revision the bootstrap binaries come from, a rebuild of all the binaries from the latest ported guix's revision is pending. How to build bootstrap binaries: On a system where GNU Guix already works: ./pre-inst-env guix build --target=powerpc64-linux-gnu bootstrap-tarballs Next steps are getting things to work on powerpc64le-linux-gnu (shouldnt be too hard now) then rebase everything onto core-updates! Leo