diff --git a/gnu/packages/glib.scm b/gnu/packages/glib.scm
index 25c5ae494b..244544ea6f 100644
--- a/gnu/packages/glib.scm
+++ b/gnu/packages/glib.scm
@@ -77,6 +77,8 @@
   #:use-module ((guix licenses) #:prefix license:)
   #:use-module (guix packages)
   #:use-module (guix utils)
+  #:use-module (guix gexp)
+  #:use-module (srfi srfi-26)
   #:use-module ((srfi srfi-1) #:hide (zip))
 
   ;; Export variables up-front to allow circular dependency with the 'xorg'
@@ -200,7 +202,15 @@ shared NFS home directories.")
     (outputs '("out"   ; everything
                "bin")) ; glib-mkenums, gtester, etc.; depends on Python
     (arguments
-     `(#:disallowed-references (,tzdata-for-tests)
+     `(#:disallowed-references
+       (,tzdata-for-tests
+        ;; Verify glib-mkenums, gtester, ... use the cross-compiled
+        ;; python.
+        ,@(if (%current-target-system)
+              (map (cut gexp-input <> #:native? #t)
+                   `(,(this-package-native-input "python")
+                     ,(this-package-native-input "python-wrapper")))
+              '()))
        #:configure-flags '("-Dman=true"
                            "-Dselinux=disabled")
        #:phases