Hey Ludo, I have reproduced the problem on the latest master targeting i686-linux and arm-linux-gnueabihf. The problem is that those libraries will fail to build when glibc is not present. Also if target os is none, this problem will not appear because the libs will not get built at all. You can reproduce it with ./pre-inst-env guix build -e '((@@(gnu packages cross-base) cross-gcc) "arm-linux-gnueabihf")' This does not happen when targeting mips. I have added an explanation to the patch and a link to this thread. Manolis