Hello:
   I want to include CAJA_EXTENSION_DIRS setup in ~/.guix-profile/etc/profile file,
and the below code seem to do not work in glib-or-gtk-build-system

  (native-search-paths
       (list (search-path-specification
              (variable "CAJA_EXTENSION_DIRS")
              (files (list "lib/caja/extensions-2.0")))

Any other steps are needed?

----------------------------------------------------------------------------------------
cat ~/.guix-profile/etc/profile
# Source this file to define all the relevant environment variables in Bash
# for this profile.  You may want to define the 'GUIX_PROFILE' environment
# variable to point to the "visible" name of the profile, like this:
#
#  GUIX_PROFILE=/path/to/profile ; \
#  source /path/to/profile/etc/profile
#
# When GUIX_PROFILE is undefined, the various environment variables refer
# to this specific profile generation.

export PATH="${GUIX_PROFILE:-/gnu/store/fial9qbkh215hydkdshw7m025m0hz741-profile}/bin:${GUIX_PROFILE:-/gnu/store/fial9qbkh215hydkdshw7m025m0hz741-profile}/sbin${PATH:+:}$PATH"
export XDG_DATA_DIRS="${GUIX_PROFILE:-/gnu/store/fial9qbkh215hydkdshw7m025m0hz741-profile}/share${XDG_DATA_DIRS:+:}$XDG_DATA_DIRS"
export XCURSOR_PATH="${GUIX_PROFILE:-/gnu/store/fial9qbkh215hydkdshw7m025m0hz741-profile}/share/icons${XCURSOR_PATH:+:}$XCURSOR_PATH"
export GUIX_GTK3_PATH="${GUIX_PROFILE:-/gnu/store/fial9qbkh215hydkdshw7m025m0hz741-profile}/lib/gtk-3.0${GUIX_GTK3_PATH:+:}$GUIX_GTK3_PATH"
export GST_PLUGIN_SYSTEM_PATH="${GUIX_PROFILE:-/gnu/store/fial9qbkh215hydkdshw7m025m0hz741-profile}/lib/gstreamer-1.0${GST_PLUGIN_SYSTEM_PATH:+:}$GST_PLUGIN_SYSTEM_PATH"
export GDK_PIXBUF_MODULE_FILE="${GUIX_PROFILE:-/gnu/store/fial9qbkh215hydkdshw7m025m0hz741-profile}/lib/gdk-pixbuf-2.0/2.10.0/loaders.cache"
export FCITX_ADDON_DIRS="${GUIX_PROFILE:-/gnu/store/fial9qbkh215hydkdshw7m025m0hz741-profile}/lib/fcitx5${FCITX_ADDON_DIRS:+:}$FCITX_ADDON_DIRS"
export HGEXTENSIONPATH="${GUIX_PROFILE:-/gnu/store/fial9qbkh215hydkdshw7m025m0hz741-profile}/lib/python3.9/site-packages/hgext3rd${HGEXTENSIONPATH:+:}$HGEXTENSIONPATH"
export GIT_EXEC_PATH="${GUIX_PROFILE:-/gnu/store/fial9qbkh215hydkdshw7m025m0hz741-profile}/libexec/git-core"
export INFOPATH="${GUIX_PROFILE:-/gnu/store/fial9qbkh215hydkdshw7m025m0hz741-profile}/share/info${INFOPATH:+:}$INFOPATH"
export EMACSLOADPATH="${GUIX_PROFILE:-/gnu/store/fial9qbkh215hydkdshw7m025m0hz741-profile}/share/emacs/site-lisp${EMACSLOADPATH:+:}$EMACSLOADPATH"


----------------------------------------------------------------------------------------------------------------
The below is caja's define:


(define-public caja
  (package
    (name "caja")
    (version "1.26.0")
    (source
     (origin
       (method url-fetch)
       (uri (string-append "mirror://mate/" (version-major+minor version) "/"
                           name "-" version ".tar.xz"))
       (sha256
        (base32
         "1m0ai2r8b2mvlr8bqj9n6vg1pwzlwa46fqpq206wgyx5sgxac052"))))
    (build-system glib-or-gtk-build-system)
    (arguments
     (list
      #:configure-flags #~(list "--disable-update-mimedb")
      #:tests? #f ; tests fail even with display set
      #:phases
      #~(modify-phases %standard-phases
          (add-before 'check 'pre-check
            (lambda _
              ;; Tests require a running X server.
              (system "Xvfb :1 &")
              (setenv "DISPLAY" ":1")
              ;; For the missing /etc/machine-id.
              (setenv "DBUS_FATAL_WARNINGS" "0"))))))
    (native-inputs
     (list pkg-config
           intltool
           `(,glib "bin")
           xorg-server
           gobject-introspection))
    (inputs
     (list exempi
           gtk+
           gvfs
           libexif
           libnotify
           libsm
           libxml2
           mate-desktop
           startup-notification))
    (native-search-paths
     (list (search-path-specification
            (variable "CAJA_EXTENSION_DIRS")
            (files (list "lib/caja/extensions-2.0")))))
    (home-page "https://mate-desktop.org/")
    (synopsis "File manager for the MATE desktop")
    (description
     "Caja is the official file manager for the MATE desktop.
It allows for browsing directories, as well as previewing files and launching
applications associated with them.  Caja is also responsible for handling the
icons on the MATE desktop.  It works on local and remote file systems.")
    ;; There is a note about a TRADEMARKS_NOTICE file in COPYING which
    ;; does not exist. It is safe to assume that this is of no concern
    ;; for us.
    (license license:gpl2+)))