I've had experiences now with multiple Guix packages, including gajim (bug 60235) and now python-neovim-remote, which have an issue where Python tries to dlopen() libc, but finds the system libc instead of Guix's, resulting on Alpine Linux hosts in a crash with this message: ImportError: libc.musl-x86_64.so.1: cannot open shared object file: No such file or directory There are a variety of tracebacks that lead up to this, depending on the package in question.