I run Guix on an Alpine Linux host system. Alpine uses the musl C library. This seems to be what exposes an issue in the gajim Guix package for me. I believe what is happening is the following: Gajim dlopen()s libc via Python's ctypes library, and ends up finding the system libc, not the Guix-provided libc it is supposed to be linked against. The result is the following crash: Traceback (most recent call last): File "/gnu/store/n2f3pi9cciaxgbvc4nhqzswslv4wycj2-gajim-1.4.6/bin/.gajim-real", line 33, in sys.exit(load_entry_point('gajim==1.4.6', 'gui_scripts', 'gajim')()) File "/gnu/store/n2f3pi9cciaxgbvc4nhqzswslv4wycj2-gajim-1.4.6/lib/python3.9/site-packages/gajim/gajim.py", line 159, in main _set_proc_title() File "/gnu/store/n2f3pi9cciaxgbvc4nhqzswslv4wycj2-gajim-1.4.6/lib/python3.9/site-packages/gajim/gajim.py", line 138, in _set_proc_title libc = CDLL(find_library('c')) File "/gnu/store/lvip6h5pamjwmvnkwg60sjb63ph8698k-python-3.9.9/lib/python3.9/ctypes/__init__.py", line 374, in __init__ self._handle = _dlopen(self._name, mode) OSError: libc.musl-x86_64.so.1: cannot open shared object file: No such file or directory