- non-root usage
    + file system virtualization needed
      * map ~/.local/gnu/store to /gnu/store
      * user name spaces?
      * [[https://github.com/proot-me/PRoot/][PRoot]]? but performance problems?
      * common interface, like “guix enter” spawns a shell where
        /gnu/store is available
    + daemon functionality as a library
      * client no longer connects to the daemon, does everything
        locally, including direct store accesses
      * can use substitutes
    + or plain ’guix-daemon --disable-root’?
    + see [[http://lists.gnu.org/archive/html/help-guix/2016-06/msg00079.html][discussion with Ben Woodcroft and Roel]]
  - central daemon usage (like at MDC, but improved)
    + describe/define appropriate setup, like:
      * daemon runs on front-end node
      * clients can connect to daemon from compute nodes, and perform
        any operation
      * use of distributed file systems: anything to pay attention to?
      * how should the front-end offload to compute nodes?
    + technical issues
      * daemon needs to be able to listen for connections elsewhere
      * client needs to be able to [[http://debbugs.gnu.org/cgi/bugreport.cgi?bug=20381][connect remotely]] instead of using
        [[http://debbugs.gnu.org/cgi/bugreport.cgi?bug=20381#5][‘socat’ hack]]
      * how do we share localstatedir?  how do we share /gnu/store?
      * how do we share the profile directory?
    + admin/social issues
      * daemon runs as root
      * daemon needs Internet access
      * Ricardo mentions lack of nscd and problems caused by the use of
        NSS plugins like [[https://fedoraproject.org/wiki/Features/SSSD][SSSD]] in this context
    + batch scheduler integration?
      * allow users to offload right from their machine to the cluster?
  - package variants, experimentation
    + for experiments, as in Section 4.2 of [[https://hal.inria.fr/hal-01161771/en][the RepPar paper]]
      * in the meantime we added [[https://www.gnu.org/software/guix/manual/html_node/Package-Transformation-Options.html][--with-input et al.]]; need more?
    + for [[https://lists.gnu.org/archive/html/guix-devel/2016-10/msg00005.html][CPU-specific optimizations]]
    + somehow support -mtune=native (and even profile-guided
      optimizations?)
    + simplify the API to switch compilers, libcs, etc.
  - workflow, reproducible science
    + implement [[http://debbugs.gnu.org/cgi/bugreport.cgi?bug=22629][channels]]
    + provide a way to see which Guix commit is used, like “guix channel
      describe”
    + simple ways to [[https://lists.gnu.org/archive/html/guix-devel/2016-10/msg00701.html][test the dependents of a package]] (see also
      discussion between E. Agullo & A. Enge)
      * new transformation options: --with-graft, --with-source
        recursive
    + support [[https://lists.gnu.org/archive/html/guix-devel/2016-05/msg00380.html][workflows and pipelines]]?
    + add [[https://github.com/galaxyproject/galaxy/issues/2778][Guix support in Galaxy]]?