There is one issue though that I get on startup:

--8<---------------cut here---------------start------------->8---
Initializing SDL 2.0.9
Failed loading "libGLU.so.1"
Failed loading GLU.  GL modes will be unavailable. Error: Passed a NULL mutex
--8<---------------cut here---------------end--------------->8---

This makes it impossible to use the Polymost / Polymer renderers.

Starting the game with something like

--8<---------------cut here---------------start------------->8---
env LD_LIBRARY_PATH=/home/ambrevar/.guix-profile/lib /gnu/store/j2f51lrgrpayclwfy77191jx3f6cpvq5-eduke32-20181027-7136/bin/eduke32 -g duke3d_hrp.zip -g duke3d_mus.zip
--8<---------------cut here---------------end--------------->8---

works.  (I have installed "glu" into my profile.)

"glu" is not in the closure of neither eduke32 not sdl2.

--8<---------------cut here---------------start------------->8---
> guix size sdl2 | grep glu
> guix size eduke32 | grep glu
--8<---------------cut here---------------end--------------->8---

It seems to be loaded at runtime.
We could wrap the "eduke32" binary, but I wonder if we could do any better.
Any advice for this?

-- 
Pierre Neidhardt
https://ambrevar.xyz/