Sorry, I misread the error message. Your error is unrelated I think, although you might need the aforementioned trick later. The problem is with libosicat. How did you install it? It seems to me that it came pre-compiled as a binary. You can check this with ldd /home/slade/.cache/common-lisp/sbcl-1.4.4-linux-x64/home/slade/quicklisp/dists/quicklisp/software/osicat-20180228-git/posix/libosicat.so (Find `ldd` in the gcc-toolchain package.) If I'm right, you need to package libosicat for Guix first so that the linker knows about the right Glibc, etc. which paths are different on Guix compared to most traditional distributions. Once you get libosicat compiled correctly (check the output of ldd to make sure there is no missing library) it should work fine. If not, try to customize cffi:*foreign-library-directories*. Let me know if you need help with osicat. -- Pierre Neidhardt https://ambrevar.xyz/