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This blog post discusses the new =E2=80=98--tune=E2=80=99 option and =E2=80= =9Cpackage multi-versioning=E2=80=9D as a way of achieving performance without giving = up on reproducibility: https://hpc.guix.info/blog/2022/01/tuning-packages-for-a-cpu-micro-archit= ecture/ I=E2=80=99ve found reproducibility to be often depicted as being detrimenta= l to performance in HPC circles, so this is a contribution to suggest otherwise. Ludo=E2=80=99.