diff --git a/gnu/packages/bioinformatics.scm b/gnu/packages/bioinformatics.scm
index fcca9ef115..6ca257245a 100644
--- a/gnu/packages/bioinformatics.scm
+++ b/gnu/packages/bioinformatics.scm
@@ -11269,56 +11269,63 @@ (define-public mrbayes
                 "1c4qg4wd6lhj1if5g6462pk15bhh7v84ys92sp47yih7lrkk2jd6"))))
     (properties `((upstream-name . "MrBayes")))
     (build-system gnu-build-system)
+    (arguments
+     (list
+      #:configure-flags '(list "--enable-sse=no"
+                               "--enable-avx=no"
+                               "--enable-fma=no"
+                               "--with-mpi"
+                               "--without-beagle")
+      #:phases
+      `(modify-phases %standard-phases
+         (add-after 'unpack 'do-not-detect-CPU-features
+           (lambda _
+             (delete-file "configure")
+             (delete-file "aclocal.m4")
+             (substitute* "configure.ac"
+               (("AC_CONFIG_AUX_DIR.*") "")
+               (("AC_CONFIG_MACRO_DIRS.*") "")
+               (("^AX_EXT") "")))))))
+    (inputs
+     (list openmpi))
     (native-inputs
-     (list automake
-           autoconf))
+     (list autoconf autoconf-archive automake pkg-config))
     (home-page "https://github.com/NBISweden/MrBayes/")
     (synopsis "Bayesian inference of phylogeny")
     (description
-     "@code{MrBayes} is a program for Bayesian inference and model choice across
-a wide range of phylogenetic and evolutionary models.  @code{MrBayes} uses @dfn{
-MCMC} (Markov chain Monte Carlo) methods to estimate the posterior distribution
-of model parameters.  Program features include:
+     "@code{MrBayes} is a program for Bayesian inference and model choice
+across a wide range of phylogenetic and evolutionary models.  @code{MrBayes}
+uses @dfn{MCMC} (Markov chain Monte Carlo) methods to estimate the posterior
+distribution of model parameters.  Program features include:
+
 @itemize
-@item
-analysis of nucleotide, amino acid, restriction site, and morphological data;
-@item
-mixing of data types, such as molecular and morphological characters, in a single
-analysis;
-@item
-easy linking and unlinking of parameters across data partitions;
-@item
-multiple evolutionary models, including 4x4, doublet, and codon models for
-nucleotide data and many of the standard rate matrices for amino acid data;
-@item
-estimation of positively selected sites in a fully hierarchical Bayesian framework;
-@item
-full integration of the @code{BEST} algorithms for the multi-species coalescent;
-@item
-estimation of time calibrated (clock) trees using a variety of (strict and)
-relaxed-clock models;
-@item
-support for complex combinations of positive, negative, and backbone constraints
-on topologies;
-@item
-model jumping across the @code{GTR} model space and across fixed rate matrices
-for amino acid data;
-@item
-monitoring of convergence during the analysis, and access to a wide range of
-convergence diagnostics tools after the analysis has finished;
-@item
-rich summaries of posterior samples of branch and node parameters printed to
-majority rule consensus trees in FigTree format;
-@item
-implementation of the stepping-stone method for accurate estimation of model
-likelihoods for Bayesian model choice using Bayes factors;
-@item
-ability to spread jobs over a cluster of computers using @code{MPI} (for
-Macintosh and UNIX environments only);
-@item
-support for the @code{BEAGLE} library, resulting in dramatic speedups for codon
-and amino acid models on compatible hardware (NVIDIA graphics cards);
-@end itemize")
+@item analysis of nucleotide, amino acid, restriction site, and morphological
+  data;
+@item mixing of data types, such as molecular and morphological characters, in
+  a single analysis;
+@item easy linking and unlinking of parameters across data partitions;
+@item multiple evolutionary models, including 4x4, doublet, and codon models
+  for nucleotide data and many of the standard rate matrices for amino acid
+  data;
+@item estimation of positively selected sites in a fully hierarchical Bayesian
+  framework;
+@item full integration of the @code{BEST} algorithms for the multi-species
+  coalescent;
+@item estimation of time calibrated trees using a variety of (strict and)
+  relaxed-clock models;
+@item support for complex combinations of positive, negative, and backbone
+  constraints on topologies;
+@item model jumping across the @code{GTR} model space and across fixed rate
+  matrices for amino acid data;
+@item monitoring of convergence during the analysis, and access to a wide
+  range of convergence diagnostics tools after the analysis has finished;
+@item rich summaries of posterior samples of branch and node parameters
+  printed to majority rule consensus trees in FigTree format;
+@item implementation of the stepping-stone method for accurate estimation of
+  model likelihoods for Bayesian model choice using Bayes factors;
+@item ability to spread jobs over a cluster of computers using @code{MPI}.
+@end itemize
+")
     (license license:gpl3)))
 
 (define-public sjcount