Hi Mădălin, > * gnu/packages/bioinformatics.scm (mrbayes): New variable. Thanks for the patch. Unfortunately, there are a few problems. - you added autoconf and automake, but neither of these is used as the git checkout includes a pre-built “configure” script and “Makefile.in” - we cannot use the “configure” script as is, because the build system uses AX_EXT, which unconditionally adds -msse* compiler flags when the CPU on the build node supports these features. This means that we cannot build a generic binary. The build system ignores “--disable-sse”, “--disable-avx”, and “--disable-fma” because of AX_EXT. - we cannot rebuild the “configure” script because the bootstrap phase fails with an error. Adding pkg-config to the native inputs does not seem to fix this either, so more investigation is needed. - consider adding openmpi and use --enable-mpi. - consider shortening the description. Especially the parts that mention proprietary software or trademarks (UNIX and Macintosh, as well as NVIDIA) should be removed. Could you please revise this and send an updated patch? -- Ricardo