Hello Guix!

On Guix System

   guix ecab53c
     repository URL: https://git.savannah.gnu.org/git/guix.git
     branch: master
     commit: ecab53c320b1584a08f811b17a92bd9a50a50ff3

it's impossible to install jupyter in a new profile because it tries to 
propagate two different versions of python-ipython, you should be able 
to reproduce with:

guix package -p /tmp/tmp-prof -i jupyter

I believe since 32ba87c14fd5e5b54d95211cd9a159d568ce7c67 many packages 
whose tests depend on version python-prompt-toolkit at version 2 yield 
conflicts when installed in a profile.

I attached a patch to propagate the right versions.

Giacomo