Hi Guix, the first patch replaces a Makefile-patching build phase with make-flags. The second patch makes samtools install its libbam library. The third patch adds the most recent version of the 0.1 line of samtools. The input and output formats differ greatly from that used and produced by samtools 1.x (which has already been packaged as "samtools") and is still used in many bioinformatics pipelines. ~~ Ricardo