Hello, the attached patch seems to be necessary to start configuring python-pyqt in core-updates. But then the configure step still fails. The error message of "guix build" is not helpful, but running the configure step in the result of "guix build -K" shows the following: ... The interpreter used by pyuic5 is /gnu/store/82nin1sk01l31p5vpnz9c2ki76qka9b0-python-wrapper-3.10.7/bin/python. Generating the C++ source for the QtCore module... Error: Unable to create the C++ code. A search seems to indicate that sip does not do its job, but the exact same error with this PyQt version does not show up. The error message comes from the function def generate_sip_module_code in configure.py, which creates a command that is run with run_command. Precisely, the command is /gnu/store/zd8nrmc0207l90vscnf7dlswd6z16aas-python-sip-5.5.0/bin/sip5 -w -n PyQt5.sip -t WS_X11 -t Qt_5_15_0 -f -P -o -y QtCore.pyi -c /tmp/guix-build-python-pyqt-5.15.8.drv-2/PyQt5-5.15.8/QtCore -I sip -I /tmp/guix-build-python-pyqt-5.15.8.drv-2/PyQt5-5.15.8/sip /tmp/guix-build-python-pyqt-5.15.8.drv-2/PyQt5-5.15.8/sip/QtCore/QtCoremod.sip If I run it by hand, it prints .sip5-real: /tmp/guix-build-python-pyqt-5.15.8.drv-1/PyQt5-5.15.8/sip/QtCore/QtCoremod.sip:23: syntax error This line 23 is very simple: %Module(name=PyQt5.QtCore, call_super_init=True, default_VirtualErrorHandler=PyQt5, keyword_arguments="Optional", use_limited_api=True, py_ssize_t_clean=True) And anyway, it is part of the source code... There is a version 5.15.9 of PyQt (interestingly enough, not related to a corresponding Qt version), with NEWS stating "Bug fixes", but what I have written above is still valid. At this point, I have to give up for lack of knowledge about sip. Andreas