After installing papirus-icon-theme my profile build became much slower, and after a few more generations I ran out of Inodes. After probing around with du I found that each profile had nearly 1.5M Inodes.
From 'du --inodes -d 1 /gnu/store | sort -n'
427406 /gnu/store/7038q3mds728lps7vrmn5ii4hzym4bs3-profile
1427426 /gnu/store/bkj5cqbq8r1kbh34w06548c6zhkf7f37-profile
1427440 /gnu/store/wjw3d19nyi838adf1gbx34yg00gws4ym-profile
1427449 /gnu/store/nxks5r9xg62av8c9harkcyk5x9ig45ka-profile
10900648 /gnu/store
And then further in the culprit: 19 /gnu/store/nxks5r9xg62av8c9harkcyk5x9ig45ka-profile/share/icons/hicolor
279659 /gnu/store/nxks5r9xg62av8c9harkcyk5x9ig45ka-profile/share/icons/ePapirus-Dark
279663 /gnu/store/nxks5r9xg62av8c9harkcyk5x9ig45ka-profile/share/icons/ePapirus
288689 /gnu/store/nxks5r9xg62av8c9harkcyk5x9ig45ka-profile/share/icons/Papirus
288689 /gnu/store/nxks5r9xg62av8c9harkcyk5x9ig45ka-profile/share/icons/Papirus-Dark
288689 /gnu/store/nxks5r9xg62av8c9harkcyk5x9ig45ka-profile/share/icons/Papirus-Light
1425409 /gnu/store/nxks5r9xg62av8c9harkcyk5x9ig45ka-profile/share/icons/
Here is my guix describe
Generation 2 Feb 04 2023 19:09:15 (current) guix f57e20d
branch: master
commit: f57e20d7289911a3691f089603c47cfdb828ea44