Today I started R (from Emacs). I needed mefa::rep.data.frame, so I ran "guix install r-mefa -p ../prof" (actually guix package -p ../prof -m ../manifest.scm, but that shouldn't matter for the purposes of the bug report) (r-mefa is not in the guix repo yet) Now it is installed, I typed in the R prompt: > mefa::rep.data.frame Error in loadNamespace(name) : there is no package called ‘mefa’ The solution is to exit the R prompt and restart. Can we do better? It appears the search path is set with .libPaths: > .libPaths function (new) { if (!missing(new)) { new <- Sys.glob(path.expand(new)) paths <- c(new, .Library.site, .Library) paths <- paths[dir.exists(paths)] .lib.loc <<- unique(normalizePath(paths, "/")) } else .lib.loc } > .libPaths() [1] "/gnu/store/5cgx6pkhr300v706sv46gx9ypnwanngw-profile/site-library" [2] "/gnu/store/6laxfxgjxnisi5fzhvqv82wjrgs7q0md-r-minimal-4.0.4/lib/R/library" It seems like the symbolic link of ../prof is dereferenced to /gnu/store/5cgx6pkhr300v706sv46gx9ypnwanngw-profile. Promising is the documentation (? base::normalizePath) of base::normalizePath: [...] Where the Unix-alike platform supports it attempts to turn paths into absolute paths in their canonical form (no ‘./’, ‘../’ nor **symbolic links**). [...] (emphasis mine) Maybe we make a copy of normalizePath (base:::guix_normalizeLibraryPath?) doing the same as base::normalizePath but without dereferencing symbolic links, and adjust .libPaths to use our variant base:::guix_normalizeLibraryPath instead of normalizePath? Greetings, Maxime.