I've been digging through the source, and it seems as though `python-build-system` does not actually set the $GUIX_PYTHONPATH variable in the environment. That variable seems to only be set by `python-2.7` and its derivatives, including `python3.9`, during a step after the install process. I don't know if this is intended. If it is, that would mean that (currently) there is no easy way to set the $GUIX_PYTHONPATH variable outside of installing `python` in a profile. That would certainly be the most expedient way forward (and how it would be done on traditional distros). Right now, beets is still calling the version of python in `/gnu/store`, but since it isn't installed alongside `beets` as a propagated-input the post-install step which sets that variable (which is called `install-sitecustomize.py` and relies of the package version of the python package being installed) is never run, and therefore the environment variable remains unset in the profile. Both `guix install python` and `export GUIX_PYTHONPATH=/gnu/..../site-packages` work to allow the environment variable to be set. But it might be better and more future-proof to just install python in the profile as a dependency, since the program itself actually depends on `python` anyway. What do You think? Here is the relevant code, from /gnu/packages/python.scm. ```scheme ;Top of file (define* (customize-site version) "Generate a install-sitecustomize.py phase, using VERSION." `(lambda* (#:key native-inputs inputs outputs #:allow-other-keys) (let* ((out (assoc-ref outputs "out")) (site-packages (string-append out "/lib/python" ,(version-major+minor version) "/site-packages")) (sitecustomize.py (assoc-ref (or native-inputs inputs) "sitecustomize.py")) (dest (string-append site-packages "/sitecustomize.py"))) (mkdir-p site-packages) (copy-file sitecustomize.py dest) ;; Set the correct permissions on the installed file, else the byte ;; compilation phase fails with a permission denied error. (chmod dest #o644)))) ---8<----------------------------------------------------------------- ; python2.7 definition ... ... (add-after 'install 'install-sitecustomize.py ,(customize-site version))))) ```