This issue still persists. Here is my describe

Generation 58 Mar 20 2023 23:24:05 (current)
guix b4fb941
repository URL: https://git.savannah.gnu.org/git/guix.git
branch: master commit: b4fb941957ea68a5e708525a8bebeacdc3d70959

And Papirus has 112035 inodes

112035 /gnu/store/ancyil1arc8c9bkf3izp66a7n9wyq3a9-papirus-icon-theme-20230104

With nearly 1.5 million in each profile. Just uninstalling and reinstalling it twice moved my inode usage from 49% to 73%

279659 /gnu/store/a3lfb69pzllcbahpkh8vaxlg7czhr9k8-profile/share/icons/ePapirus-Dark
279663 /gnu/store/a3lfb69pzllcbahpkh8vaxlg7czhr9k8-profile/share/icons/ePapirus
288689 /gnu/store/a3lfb69pzllcbahpkh8vaxlg7czhr9k8-profile/share/icons/Papirus
288689 /gnu/store/a3lfb69pzllcbahpkh8vaxlg7czhr9k8-profile/share/icons/Papirus-Dark288689 /gnu/store/a3lfb69pzllcbahpkh8vaxlg7czhr9k8-profile/share/icons/Papirus-Light

It is worth noting that Papirus is not alone in making too many inodes per profile, it is just the most noticeable given how huge it is. Breeze will saturate one's inodes after a about 200 generations.

27261 /gnu/store/v71lm9qcpvl2bayclc1j83hfbm91r2ff-profile/share/icons/breeze-dark
29738 /gnu/store/v71lm9qcpvl2bayclc1j83hfbm91r2ff-profile/share/icons/breeze

And maybe others.