I can confirm that on Guix System mpv also fails after the upgrade to 0.35 . Mpv won't play videos but it can play audio in the terminal. When trying to play videos it will give the following error: "[vo/gpu] VT_GETMODE failed: Inappropriate ioctl for device [vo/gpu/opengl] Failed to set up VT switcher. Terminal switching will be unavailable. amdgpu_device_initialize: amdgpu_query_info(ACCEL_WORKING) failed (-13) amdgpu: amdgpu_device_initialize failed. [vo/gpu] Failed to commit ModeSetting atomic request (-13) [vo/gpu/opengl] Failed to set CRTC for connector 66: Permission denied Error opening/initializing the selected video_out (--vo) device. Video: no video Exiting... (Errors when loading file)" This also sometimes causes the desktop environment to crash and go to the login screen. A quick google search indicates that this seems to happen because mpv now needs libxpresent to work with x11 (just like Jorge P. de Morais said above ): Mpv Issue no. 10327 Arch Linux package mpv-git Mpv Issue no. 9773 I would submit a patch to fix this if I was better at guile. Is someone out there up to the task? Cheers Markus