Hi, I'm still quite puzzled by this, but I'm relatively confident that commit 2986ba899f5ee374008c501e26fb653147ed7891 ("gnu: cups: Replace with 2.4.6 [fixes CVE-2023-34241].") caused the following wxPython / pygobject script to fail: --8<---------------cut here---------------start------------->8--- $ guix time-machine --commit=2986ba899f5ee374008c501e26fb653147ed7891 \ -- shell --rebuild-cache --pure python python-pygobject python-wxpython gtk+ \ -- ./hang-repro.py --8<---------------cut here---------------end--------------->8--- Where hang-repro.py contains: