I talked with mark weaver about this on #guix and he asked me to send a mail. When doing guix package -i sbcl on my newly setup debian testing + guix machine and then attempting to run sbcl I got the error: fatal error encountered in SBCL pid 7492(tid 140737354086144): can't find core file at /usr/lib64/sbcl/sbcl.core Exporting SBCL_HOME=$HOME/.guix-profile/lib/sbcl fixes this for me. The way this seems to be handled other places is by printing a message after the package install explaining that this may be needed. This seems like the appropriate thing to do to me. I'd love to submit a patch if someone can guide me through it, I just started seriously trying guix out today. Thanks, Christopher Carpenter P.S. Please make sure to CC me in replies, I have not joined the mailing list (yet).