The u-boot package definition includes openssl amoung it's inputs, but is also a GPL2+ software project... but the GPL and OpenSSL licenses are incompatible: https://www.gnu.org/licenses/license-list.html#OpenSSL It doesn't explain the details of *why* they're incompatibly, which is astoundingly unhelpful. The best explanation I've found is here: https://people.gnome.org/~markmc/openssl-and-the-gpl.html Essentially, the Openssl/SSLeay license(s) place additional restrictions requiring "advertising" clause when distributing in binary form, while the GPL forbids placing additional restrictions on distribution. I'm not sure if there's a simple way to search for other packages with license:gpl and openssl as an input in order to do a quick pass at auditing... some packages may use the openssl binary as part of the build process or tests, and not linking any GPLed code against it; in those cases there would be no license conflict. Since I believe the incompatibility is only invoked when distributing binaries, GNU Guix may be in an interesting position to at least make a simple workaround for affected packages by using: (arguments `(#:substitutable? #f)) Thus disabling substitutes. Though it poses a curious philosophical question weather that is an acceptible/appropriate workaround for GNU Guix... In the Debian u-boot packaging, some of the features using openssl are disabled, and some of the u-boot targets that require openssl are not part of the packages. I'd be happy to help with making such adjustments if this is deemed the better approach for u-boot specifically. Other more long-term approaches: Patch (and submit upstream) the affected packages to support using other GPL compatible libraries, such as gnutls. If upstream is reasonably able to add a license exception, that could also resolve the issue: https://www.gnu.org/licenses/gpl-faq.html#GPLIncompatibleLibs live well, vagrant