Could you give it a try and refine as needed?  :-)

> I asked about this on #debian-reproducible and they said that it wasn't
> an issue for Debian since they don't ship bytecode, but instead generate
> it at install time. Of course, that doesn't really apply to Guix.

I’d recommend trying #reproducible-builds on OFTC, which is more
generic.  Also, in some cases, it’s useful to look at
<git://git.debian.org/git/reproducible/notes.git>, which contains notes
about non-reproducible packages (currently partly Debian-specific, but
we need to lobby to make it more generic.  ;-))

Thanks,
Ludo’.