diff --git a/gio/gdesktopappinfo.c b/gio/gdesktopappinfo.c
index f1e2fdd..96dcc32 100644
--- a/gio/gdesktopappinfo.c
+++ b/gio/gdesktopappinfo.c
@@ -161,6 +161,7 @@ static DesktopFileDir *desktop_file_dir_user_config = NULL;  /* (owned) */
 static DesktopFileDir *desktop_file_dir_user_data = NULL;  /* (owned) */
 static GMutex          desktop_file_dir_lock;
 static const gchar    *gio_launch_desktop_path = NULL;
+static GFileMonitor   *guix_profile_monitor = NULL;
 
 /* Monitor 'changed' signal handler {{{2 */
 static void desktop_file_dir_reset (DesktopFileDir *dir);
@@ -230,6 +231,22 @@ desktop_file_dir_get_alternative_dir (DesktopFileDir *dir)
   return parent;
 }
 
+static void
+guix_profile_changed  (GFileMonitor      *monitor,
+                       GFile             *file,
+                       GFile             *other_file,
+                       GFileMonitorEvent  event_type,
+                       gpointer           user_data)
+{
+  DesktopFileDir *dir = user_data;
+
+  desktop_file_dir_reset (dir);
+
+  /* When ~/.guix-profile changes, emit the 'changed' signal so everyone
+     knows.  */
+  g_app_info_monitor_fire ();
+}
+
 static void
 desktop_file_dir_changed (GFileMonitor      *monitor,
                           GFile             *file,
@@ -1531,6 +1548,7 @@ desktop_file_dirs_lock (void)
 
   if (desktop_file_dirs == NULL || desktop_file_dirs->len == 0)
     {
+      const gchar *home;
       const char * const *dirs;
       gint i;
 
@@ -1555,6 +1573,27 @@ desktop_file_dirs_lock (void)
       for (i = 0; dirs[i]; i++)
         g_ptr_array_add (desktop_file_dirs, desktop_file_dir_new (dirs[i]));
 
+      home = g_get_home_dir ();
+      if (guix_profile_monitor == NULL && home != NULL)
+        {
+          DesktopFileDir *dir;
+          const gchar *profile, *data_dir;
+          profile = g_build_filename (home, ".guix-profile", NULL);
+          data_dir = g_build_filename (profile, "share", NULL);
+          dir = desktop_file_dir_new (data_dir);
+
+          /* Monitor ~/.guix-profile and treat modifications to
+             ~/.guix-profile as if they were modifications to
+             ~/.guix-profile/share.  */
+          guix_profile_monitor =
+            g_local_file_monitor_new_in_worker (profile, FALSE, G_FILE_MONITOR_NONE,
+                                                guix_profile_changed,
+                                                desktop_file_dir_ref (dir),
+                                                closure_notify_cb, NULL);
+
+          g_ptr_array_add (desktop_file_dirs, desktop_file_dir_ref (dir));
+        }
+
       /* The list of directories will never change after this, unless
        * g_get_user_config_dir() changes due to %G_TEST_OPTION_ISOLATE_DIRS. */
       desktop_file_dirs_config_dir = user_config_dir;