Hello, On the current 'master' branch, using an inferior in a manifest will cause a crash in 'compute-guix-derivation' as reported in . It can be reproduced by taking the inferior example from the manual: https://guix.gnu.org/manual/en/guix.html#Inferiors ..and running 'guix build --no-grafts -n -m inferior-example.scm'. I've attempted to bisect it, but it is difficult because once you have successfully passed 'compute-guix-derivation', the problem is no longer reproducible, even on known "bad" commits. So for every successful test a new commit/channel must be chosen. Here is a backtrace from a bad commit: Backtrace: In ice-9/boot-9.scm: 152:2 19 (with-fluid* _ _ _) 152:2 18 (with-fluid* _ _ _) 142:2 17 (dynamic-wind _ _ #) 829:9 16 (catch _ _ # …) 829:9 15 (catch _ _ # …) 152:2 14 (with-fluid* _ _ _) 152:2 13 (with-fluid* _ _ _) 142:2 12 (dynamic-wind _ _ #) 152:2 11 (with-fluid* _ _ _) 152:2 10 (with-fluid* _ _ _) 152:2 9 (with-fluid* _ _ _) 705:2 8 (call-with-prompt ("build handler") # …) In unknown file: 7 (_ # …) In ice-9/eval.scm: 619:8 6 (_ #(#(#(#) # …) …)) 626:19 5 (_ #(#(#(#) # …) …)) In guix/derivations.scm: 357:5 4 (substitution-oracle # …) 329:16 3 (derivation-input-fold # …) In ice-9/eval.scm: 619:8 2 (_ #(#(#(#(#) …) …) …)) 619:8 1 (_ #(#(# # …))) In unknown file: 0 (put-bytevector # #vu8(1 0 …) …) ERROR: In procedure put-bytevector: In procedure put-bytevector: Wrong type argument in position 1 (expecting open output port): #