After several weeks of not using a machine, and updating guix to guix (GNU Guix) c04ffadbed7412545555b8be6b78f23eed150d26 Running "guix build system /etc/config.scm" resulted in: guix system: error: failed to load '/etc/config.scm': /etc/config.scm:23:9: /etc/config.scm:23:9: In procedure allocate-struct: Wrong type argument in\ position 2: 3 This roughly corresponded to my mapped device section in /etc/config.scm: (mapped-devices (list (mapped-device (source (uuid "c106e43e-0479-4135-a1a8-b5221312bf74")) (target "cryptic") (type luks-device-mapping)))) Moving it all into a single line worked around the issue, but is a good deal harder to read: (mapped-devices (list (mapped-device (source (uuid "c106e43e-0479-4135-a1a8-b5221312bf74")) (target "cryptic") (type luks-device-mapping)))) My guess is it has something to do with some commits relating to validating mapped devices: 42ff7d3be642d66ba567f64882a1f2301b1a7bd9 mapped-devices: 'luks-device-mapping' checks its source device. 4ca90ff5976434a2b6e758df38df54387ae70c1b mapped-devices: Add 'location' and 'check' fields. Hope that helps! live well, vagrant