Hey George, On Sat, Apr 28 2018, George myglc2 Clemmer wrote: > g1@sysi17 ~ [env]$ guix environment > --substitute-urls=https://g1.local:8080 The guix substitute command only runs a normal http server, so you have to use http://, not https://. I think the other servers you mention are behind proxies which handle the SSL part and forward the requests on to the substitute process. Does it work if you run this instead? guix environment --substitute-urls=http://g1.local:8080 Carlo