diff --git a/guix/scripts/repl.scm b/guix/scripts/repl.scm
index 7d4e474e92..b672489ed6 100644
--- a/guix/scripts/repl.scm
+++ b/guix/scripts/repl.scm
@@ -22,6 +22,7 @@
   #:use-module (guix ui)
   #:use-module (guix scripts)
   #:use-module (guix repl)
+  #:autoload   (gnu packages) (%package-module-path)
   #:use-module (srfi srfi-1)
   #:use-module (srfi srfi-26)
   #:use-module (srfi srfi-37)
@@ -173,6 +174,10 @@ call THUNK."
   (with-error-handling
 
     (unless (null? script)
+      ;; Before running SCRIPT, initialize %PACKAGE-MODULE-PATH so that it
+      ;; contains the user's channels (the statement triggers an autoload).
+      (%package-module-path)
+
       ;; Run script
       (save-module-excursion
        (lambda ()