For the record, I attached the failed build log for current core- updates. $ ./pre-inst-env guix describe Git checkout: repository: /home/lle-bout/src/guix branch: core-updates commit: cc6cb6e80a42355147809b4830053a34d1563994 Build command: $ ./pre-inst-env guix build --target=powerpc64le-linux-gnu bootstrap- tarballs The most important bit in the build log is: configure: error: *** The compiler must support -mabi=ieeelongdouble and -mlongdouble simultaneously. This particular error does not happen with the GCC 7.x and Glibc 2.31 combo.