The following phase works around the issue for me (for antioxidant) -- this makes "guix build --check" pass (at least for antioxidant): > +    ;; TODO: SOURCE_DATE_EPOCH support would be nice.  Also maybe > better fit for a snippet? > +    ;; > +    ;; Make the rust-vergen reproducible and avoid causing > irreproducibility > +    ;; in dependents. > +    ("rust-vergen" > +     ,#~((add-after 'unpack 'remove-timestamp-irreproducibility > +       (lambda _ > +         (substitute* (find-files "." "\\.rs$") > +           (("^extern crate chrono;") "extern crate chrono; use > chrono::Utc; use chrono::TimeZone;") > +           (("^use chrono::Utc;") "use chrono::Utc; use > chrono::TimeZone;") Should also work for cargo-build-system, but untested. Greetings, Maxime