I was able to reproduce it on a fresh install of Guix 1.3.0. I just downloaded the image, installed with graphical installer, and ran "guix pull" and "guix system reconfigure /etc/config.scm" on the freshly installed system. Then, "guix install lsh" checks for substitues and falls back to building, which results in the attached error message. I also tried installing lsh in the QCOW2 image, which got it installed from substitutes without an issue. It seems that something in build- dependancies needs to be updated. Roman