Hello there. I ran in bash shell: pwd --> /home/vits conf=~/guix/configuration/configuration.scm ls $conf # file exists --> ~/guix/configuration/configuration.scm guix system build $conf --> guix system: error: failed to load '/home/vits/guix/configuration/configuration.scm': No such file or directory The commands above will result in a successfull build if i `cd guix/configuration` before doing `guix system build` (both with rel. and abs. names). Attached is WORKING config.scm. Error was caused by local-file() used with _relative_ paths. Those were commented out, and this config.scm works from any directory. #guix: > ... error message is very misleading. Better of course if the offending file will be print out: "failed to load (...) /home/vits/auto-login: no such file or directory" --- Thanks for attention, Vitaliy.