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charset=UTF-8 Content-Transfer-Encoding: quoted-printable > Back to your snippet =E2=80=94 if you still think it's worth trying (to s= ee if > it gets rid of the ENOENTs), I'll try it and report later. Starting from guix 3bb3fddb5c6e79056172e5858cdc0ee0b6b8cfaa, I tried adding this --8<---------------cut here---------------start------------->8--- #:phases #~(modify-phases %standard-phases (add-after 'install 'customize-texmfcnf.lua (lambda _ (substitute* (string-append #$output "/share/texmf-dist/web2c/texmf= cnf.lua") (("selfautodir:") #$output) (("selfautoparent:") (string-append #$output "/share/")))))))) --8<---------------cut here---------------end--------------->8--- to `texlive-luatex` as suggested. I verified manually that the file in the resulting package actually got the paths substituted. I then ran --8<---------------cut here---------------start------------->8--- guix shell -D guix -- path/to/pre-inst-env guix shell texlive-collection-la= tex less coreutils grep findutils which strace -C strace lualatex minimal.tex > strace.txt 2>&1 grep -E 'lualatexquotejobname.*ENOENT' strace.txt | wc -l --8<---------------cut here---------------end--------------->8--- and got 9138 --Sig_/vdZWZooeRuKb.xqBQXcqGSh Content-Type: application/pgp-signature Content-Description: OpenPGP digital signature -----BEGIN PGP SIGNATURE----- iHUEARYIAB0WIQTpcnBg48VjfIpPS0JLxSIcWnn9GgUCZMQyNwAKCRBLxSIcWnn9 GiQwAP0aoOLyqJrMnFinxyXKBf8B/LVbtRYpG+NDFhkCz2XvOAD9Hi+0m1asi4tt 5JwnlPZEcq4/6PbE0kU152JlBZWxowE= =LHfx -----END PGP SIGNATURE----- --Sig_/vdZWZooeRuKb.xqBQXcqGSh--