Hi, this issue is similar to https://issues.guix.gnu.org/41702, but I’m not sure it’s exactly the same. For guix-science I’m trying to provide some packages like python-jupyterlab, which depend on a mix of packages from guix proper and newer versions of packages already included in guix proper. Thus I need to rewrite inputs of the former to the latter. (Because Python only propagates dependencies and thus collisions would occur.) Previously I have been doing this using package-input-rewriting, but starting an environment containing python-jupyterlab alone took about 20s (warm caches, all derivations in the store). Manually rewriting inputs by inheriting and alist-delete’ing brings this down to 3s, which is pretty significant. --no-grafts has not much of an impact (15s vs 2s) here. See https://github.com/guix-science/guix-science/commit/972795a23cc9eb5a0bb1a2ffb5681d151fc4d4b0 for the exact changes. My expectation would be that package-input-rewriting is the preferred, because easier, solution to this problem and thus should have minimal impact on performance. Cheers, Lars