This bug report sounds absurd to me but I don't see anything else obvious that changed. I reconfigured with (kernel linux-libre) and the gpg-agent couldn't find any pinentry. I even tried killing gpg-agent and manually launching it and giving it the path to pinentry. I then changed to (kernel linux-libre-5.7) and used the same commit to reconfigure and gpg-agent started working as expected again. I added and removed the qemu-binfmt-service-type before the first failure with 5.8 and after 5.7 worked. I've attached my os config, and here's a link¹ to the repo. (ins)efraim@E5400 ~$ guix describe Generation 58 Aug 24 2020 23:35:45 (current) guix c88bccc repository URL: https://git.savannah.gnu.org/git/guix.git commit: c88bccc14e29fceb0ac2b139cb5c73546bcee352 ¹ https://gitlab.com/Efraim/guix-config/-/tree/25470123d5a87c064f52ec4e0d939928bd22500c -- Efraim Flashner אפרים פלשנר GPG key = A28B F40C 3E55 1372 662D 14F7 41AA E7DC CA3D 8351 Confidentiality cannot be guaranteed on emails sent or received unencrypted