I'm afraid I can reproduce it. I'm at revision bfe3c6857251c1fff24317da602b9cd762c1c112, running guix from GIT through pre-inst-env. I was able to remove all my local modifications so no GUIX_PACKAGE_PATH is in place. ----------------------%<----my-config.scm----begin---->%------------------- (use-modules (gnu)) (use-package-modules ;; generic guix packages modules admin autotools avahi base bash commencement cryptsetup curl emacs enlightenment gdb glib gnutls gnuzilla grub links linux lsh mail mc patchutils slim synergy texinfo version-control video wget wicd xfce xorg dwm avahi ssh xorg vpn openssl) (use-service-modules avahi base dbus networking ssh xorg) (operating-system (host-name "venom") (timezone "Europe/Prague") (locale "cs_CZ.utf8") (bootloader (grub-configuration (device "/dev/sda") (menu-entries (list (menu-entry (label "Gentoo") (linux "/vmlinuz-gentoo") (linux-arguments (list "root=/dev/venom/gentoo" "init=/usr/lib/systemd/systemd")) (initrd "/initramfs-gentoo") ))))) (file-systems (append (list (file-system (device "/dev/sda3") ; or partition label (mount-point "/") (type "ext4")) ;; (file-system ;; (device "/dev/venom/home") ;; (mount-point "/home") ;; (type "ext4")) ) %base-file-systems)) (swap-devices '("/dev/sda2")) (users (list (user-account (name "tcech") (uid 1000) (group "users") (comment "Tomas Cech") (password "password") (home-directory "/home/tcech")))) (packages (append (list ;; absolutely necessary emacs lvm2 mc bash texinfo grub nss-mdns procps cryptsetup alsa-utils ;; networking iw iproute wicd links wpa-supplicant dbus vpnc openconnect openssl lsh ;; minimal Xorg slim xrandr xterm slock ;; mail mutt mu gnutls ;; web icecat wget curl ;; enlightenment terminology enlightenment ;; xfce xfce ;; other X stuff synergy ;; multimedia mplayer mplayer2 vlc ;; mpv ;; development git magit subversion cvs rcs quilt patchutils patch gcc-toolchain-4.9 gnu-make automake autoconf gdb strace ltrace ;; other htop ;; not packaged yet ;; isync cmus cscope ctags the-silver-searcher ) %base-packages)) (services (append (list (lsh-service #:port-number 22 #:root-login? #t #:initialize? #t) (slim-service) (wicd-service) (avahi-service) (dbus-service (list avahi wicd)) (mingetty-service "ttyS0")) %base-services)) ) ----------------------%<----my-config.scm----end------>%------------------- As I lost ability to boot after repartitioning so I run it from chroot from openSUSE. Guix daemon is started from chroot. Failure is happening with: $ guix system reconfigure my-config.scm substitute-binary: updating list of substitutes from 'http://hydra.gnu.org'... The following derivations will be built: /gnu/store/igkyyxgpyvizzpkygji34dkyiivrbqbj-system.drv /gnu/store/khgv41ycwz0vg6sadgzrbrpsl93mii5c-grub.cfg.drv /gnu/store/j1s6vh555l6bjmf343wf9f1iyzdzwnv8-activate.drv /gnu/store/mx0rmnfqi998lpdv8iaywj66wdjnhmsy-boot.drv /gnu/store/wnj7qwhn1i7akk6crkg6s0diksi3lhyr-pam.d.drv /gnu/store/7dm59cc020dfma43b24pilrp98zgsbs8-etc.drv Backtrace: In ice-9/boot-9.scm: 157: 10 [catch #t # ...] In unknown file: ?: 9 [apply-smob/1 #] In ice-9/boot-9.scm: 63: 8 [call-with-prompt prompt0 ...] In ice-9/eval.scm: 432: 7 [eval # #] In ice-9/boot-9.scm: 2401: 6 [save-module-excursion #] 4050: 5 [#] 1724: 4 [%start-stack load-stack ...] 1729: 3 [#] In unknown file: ?: 2 [primitive-load "/gnu/store/b027n4gx00y19bpyi1h5hasvnpp95ff4-pam.d-builder"] In srfi/srfi-1.scm: 616: 1 [for-each # (# # # # ...)] In unknown file: ?: 0 [symlink "/gnu/store/z95z25d73kjza99s3w95lrdsiqlcdv0a-login" ...] ERROR: In procedure symlink: ERROR: In procedure symlink: File exists builder for `/gnu/store/wnj7qwhn1i7akk6crkg6s0diksi3lhyr-pam.d.drv' failed with exit code 1 cannot build derivation `/gnu/store/7dm59cc020dfma43b24pilrp98zgsbs8-etc.drv': 1 dependencies couldn't be built cannot build derivation `/gnu/store/igkyyxgpyvizzpkygji34dkyiivrbqbj-system.drv': 1 dependencies couldn't be built killing process 7202 guix system: error: build failed: build of `/gnu/store/igkyyxgpyvizzpkygji34dkyiivrbqbj-system.drv' failed It seems to be identical to the report. Furthermore - `make clean' in my GIT repository is not helping so right now I'm not sure how to progress. I'd appreciate if you have any other hints how to progress or what else to wipe. S_W