Broken: $ guix shell --pure inkscape -- inkscape (crashes on start with ‘Inkscape encountered an internal error and will close now’.) Work-around: $ guix shell --pure inkscape gdk-pixbuf -- inkscape also works: $ guix shell --pure inkscape gdk-pixbuf -- /usr/bin/env GDK_PIXBUF_MODULE_FILE=/gnu/store/[...]-profile/lib/gdk-pixbuf-2.0/2.10.0/loaders.cache inkscape Looks like some wrapping is required to point GDK_PIXBUF_MODULE_FILE to an appropriate 'loaders.cache'. Also starts in a non-pure environment without adding extra packages, but then the icons aren't found. Greetings, Maxime.