This is not working for me (guile 2.0.11). See below. In addition I have tried other items.
(In addition, when I "sudo -s" to install under /opt/local, I end up with guild support modules owned by root in my ~/.cache dir.)
mwette$ ls -l share/guile/site/2.0/nyacc/
total 184
-rw-r--r-- 1 root admin 69804 Jul 4 18:51 lalr.scm
-rw-r--r-- 1 root admin 13564 Jul 4 18:51 lex.scm
-rw-r--r-- 1 root admin 4041 Jul 4 18:51 util.scm
mwette$ ls -l lib/guile/2.0/site-ccache/nyacc/
total 272
-rw-r--r-- 1 root admin 111444 Jul 4 18:53 lalr.scm.go
-rw-r--r-- 1 root admin 15367 Jul 4 18:53 lex.scm.go
-rw-r--r-- 1 root admin 5470 Jul 4 18:53 util.scm.go
mwette$ GUILE_LOAD_PATH= guile calc.scm
;;; note: auto-compilation is enabled, set GUILE_AUTO_COMPILE=0
;;; or pass the --no-auto-compile argument to disable.
;;; compiling /Users/mwette/proj/scheme/myproj/lalr1/dist/test-suite/nyacc/calc.scm
;;; compiling /opt/local/share/guile/site/2.0/nyacc/lalr.scm
;;; compiling /opt/local/share/guile/site/2.0/nyacc/util.scm
;;; compiled /Users/mwette/.cache/guile/ccache/2.0-LE-8-2.0/opt/local/share/guile/site/2.0/nyacc/util.scm.go
;;; compiled /Users/mwette/.cache/guile/ccache/2.0-LE-8-2.0/opt/local/share/guile/site/2.0/nyacc/lalr.scm.go
;;; compiling /opt/local/share/guile/site/2.0/nyacc/lex.scm
;;; compiled /Users/mwette/.cache/guile/ccache/2.0-LE-8-2.0/opt/local/share/guile/site/2.0/nyacc/lex.scm.go
;;; compiled /Users/mwette/.cache/guile/ccache/2.0-LE-8-2.0/Users/mwette/proj/scheme/myproj/lalr1/dist/test-suite/nyacc/calc.scm.go
2
mwette$