The srfi-69 implementation that comes with Guile doesn't function properly when some non-false #:weak argument is provided. The problems seems to be that it tries to use handles, which are only available for non-weak hash-tables.

scheme@(guile-user)> (import (srfi :69))
scheme@(guile-user)> (define ht (make-hash-table eq? hashq #:weak 'key))
scheme@(guile-user)> (hash-table-set! ht 10 10)
ERROR: In procedure hashx-create-handle!:
In procedure scm_hash_fn_create_handle_x: Wrong type argument in position 1 (expecting hash-table): #<weak-table 0/31>

Entering a new prompt. Type `,bt' for a backtrace or `,q' to continue.
scheme@(guile-user) [1]>

Regards,

Jessica